Dr. Yasutomi Higashikuni is an Associate Professor of Cardiovascular Medicine at Osaka Metropolitan University. His research interests include homeostatic inflammation, RNA metabolism and modification, aging, and synthetic biology in cardiovascular medicine. He is leading a new research field, “Synthetic Cardiology”, which creates novel gene and cell therapies that enable automatic reversal of aging phenotypes and maintenance of homeostasis.
Interests
- Synthetic Cardiology
- Homeostatic Inflammation
- RNA Metabolism and Modification
- Aging
Education
Ph.D. in Internal Medicine, 2010
The University of Tokyo
M.D., 2002
The University of Tokyo
Latest
- Emerging roles of the cGAS/STING pathway in cardiovascular diseases
- Just published in Journal of Clinical Investigation!!
- Fulminant Lupus Myocarditis as the Initial Manifestation of Systemic Lupus Erythematosus Successfully Treated with High-Dose Steroid Therapy A Case Report
- Japan Society for Vascular Failure 2026 Hyperuricemia, the Old and New Issue in Cardiovascular Medicine
- Positioning esaxerenone, a non-steroidal mineralocorticoid receptor antagonist, in the treatment of hypertension with and without hemodynamic cardiac stress
- JCS2026 Linking inflammation to heart failure
- JCS2026 RNA dynamics and post-translational modifications in cardiac aging
- JCS2026 Controlling molecular dynamics for the treatment of heart failure
- The Japanese Pharmacological Society Scientific Meeting 2026 RNA metabolism in heart failure
- Japanese Society of Gout and Uric and Nucleic Acids Uric acid and Heart failure
- Sustained HIF activation in adult cardiomyocytes show transient beneficial effect in murine HFpEF model
- BCVR2025 Linking inflammation to metabolic changes in heart disease
- Compound heterozygous variants of CACNA1H change channel properties and contribute to intractable epilepsy with myoclonic-atonic seizures
- LPS Induces Limited Activation of Hypoxia-Inducible Factor-1a (HIF-1a) in Macrophages
- Hyperuricemia, the Old and New Issue in Cardiovascular Medicine
- JCC2025 Cardiac inflammatory signaling in health and disease
- ESC2025 RNA metabolism in heart disease
- 58th Lake Kawaguchi Conference of Cardiology Inflammatory signaling in heart disease
- Hyperuricemia, the Old and New Issue in Cardiovascular Medicine
- Hyperuricemia, the Old and New Issue in Cardiovascular Medicine
- Hyperuricemia, the Old and New Issue in Cardiovascular Medicine
- SHVM2025 RNA metabolism in heart disease
- Mitigation of Doxorubicin Cardiotoxicity With Synergistic miRNA Combinations Identified Using Combinatorial Genetics en masse (CombiGEM)
- Just published in JACC CardioOncology!!
- ISHR2025 Aging and inflammatory signaling in heart disease
- CREATE-GLOBAL 2025 Inflammatory signaling in heart disease
- Japan Society for Vascular Failure 2025 Heart-Vessel Interaction
- Hyperuricemia, the Old and New Issue in Cardiovascular Medicine
- Hyperuricemia, the Old and New Issue in Cardiovascular Medicine
- Chronobiological rhythms and artificial light at night in vascular physiology and pathology
- Society of Cerebral-Cardio-Vascular Anti-Aging 2024 Inflammatory Signaling and Heart Failure
- BCVS2024 Neural Control of Cardiac Inflammation and Remodeling
- Hyperuricemia, the Old and New Issue in Cardiovascular Medicine
- MARS Seminar Inflammation and Heart Failure
- MARS Seminar Inflammation and Heart Failure
- Nocturnal blood pressure and left ventricular hypertrophy in patients with diabetes mellitus
- Self-DNA sensing in cigarette smoke-induced vascular inflammation: the role of mitochondrial DNA release in vascular endothelial cells
- How Inflammation Causes Heart Failure
- Hyperuricemia, the Old and New Issue in Cardiovascular Medicine
- Clinical valve thrombosis and arterial embolism in a cancer patient after transcatheter aortic valve replacement
- Novel Therapeutic Strategy for Cardiovascular Disease
- Heart Failure and Inflammation
- Sports Activity for Mens' Health in Cardiovascular Medicine
- Not a small frog in a big pond: targeting bradykinin receptor B2 signaling in vascular smooth muscle cells for treatment of hypertension
- Therapeutic Strategy for Hyperuricemia in Cardiovascular Medicine
- An explainable artificial intelligence-enabled electrocardiogram analysis model for the classification of reduced left ventricular function
- Optimizing antihypertensive therapy in patients with diabetes mellitus
- NLRP3 Inflammasome Activation Through Heart-Brain Interaction Initiates Cardiac Inflammation and Hypertrophy During Pressure Overload
- Deep learning-based age estimation from chest X-rays indicates cardiovascular prognosis
- Just published in Circulation!!
- Hyperuricemia in Cardiovascular Medicine
- Endoplasmic reticulum stress-activated nuclear factor-kappa B signaling pathway induces the upregulation of cardiomyocyte dopamine D1 receptor in heart failure
- Age prediction from coronary angiography using a deep neural network: Age as a potential label to extract prognosis-related imaging features
- Automatic Detection of Left Ventricular Dilatation and Hypertrophy from Electrocardiograms Using Deep Learning
- Diabetes in Cardiovascular Medicine
- Give a Leg Up: Screening for Peripheral Artery Disease after Acute Myocardial Infarction
- Linking RNA dynamics to heart disease: the lncRNA/miRNA/mRNA axis in myocardial ischemia-reperfusion injury
- Hyperuricemia in Cardiovascular Medicine
- Homeostatic Inflammation in Heart Disease
- Deep learning model to detect significant aortic regurgitation using electrocardiography
- Aging in Cardiovascular Medicine
- Deep Learning Algorithm to Detect Cardiac Sarcoidosis
- Pathogenic Basis of Thromboinflammation and Endothelial Injury in COVID-19: Current Findings and Therapeutic Implications
- Automatic detection of vessel structure by deep learning using intravascular ultrasound images of the coronary arteries
- The Effectiveness of a Deep Learning Model to Detect Left Ventricular Systolic Dysfunction from Electrocardiograms
- Welcome to Higashikuni Lab!!
- Biodegradable Extremely-Small-Diameter Vascular Graft Made of Silk Fibroin can be Implanted in Mice
- Next-Generation Therapeutic Platforms in Cardiovascular Medicine
- Diagnosing Heart Failure from Chest X-Ray Images Using Deep Learning
- Next-Generation Gene Therapy for Heart Failure
- Next-Generation Therapeutic Platforms in Cardiovascular Medicine
- Advancing CRISPR-Based Programmable Platforms beyond Genome Editing in Mammalian Cells
- Vildagliptin, a DPP-4 Inhibitor, Attenuates Endothelial Dysfunction and Atherogenesis in Nondiabetic Apolipoprotein E-Deficient Mice
- Single-Nucleotide-Resolution Computing and Memory in Living Cells
- Activation of Toll-Like Receptor 9 Impairs Blood Flow Recovery After Hind-Limb Ischemia
- Toll-Like Receptor 9 Plays a Pivotal Role in Angiotensin II-Induced Atherosclerosis
- Structure-function-guided exploration of the antimicrobial peptide polybia-CP identifies activity determinants and generates synthetic therapeutic candidates
- Advancing therapeutic applications of synthetic gene circuits
- Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance
- Giant left atrial myxoma that caused mitral valve obstruction and pulmonary hypertension
- Pioglitazone Reduces Vascular Lipid Accumulation in Angiotensin II-Induced Hypertensive Rat
- Cardiac compression by massive mediastinal haematoma due to bleeding from the ectopic bronchial artery
- Endothelial PGC-1α mediates vascular dysfunction in diabetes
- HMGB1 plays a critical role in vascular inflammation and lesion formation via toll-like receptor 9
- Toll-like receptor-2 mediates adaptive cardiac hypertrophy in response to pressure overload through interleukin-1β upregulation via nuclear factor κB activation
- Discordance of the areas of peak wall shear stress and tissue stress in coronary artery plaques as revealed by fluid-structure interaction finite element analysis: a case study
- The ATP-binding cassette transporter ABCG2 protects against pressure overload-induced cardiac hypertrophy and heart failure by promoting angiogenesis and antioxidant response
- Aliskiren in combination with valsartan exerts synergistic protective effects against ventricular remodeling after myocardial infarction in mice
- The ATP-binding cassette transporter BCRP1/ABCG2 plays a pivotal role in cardiac repair after myocardial infarction via modulation of microvascular endothelial cell survival and function
- Serum osteoprotegerin levels and long-term prognosis in subjects with stable coronary artery disease
- Difference of culprit plaque composition between patients with and without pre-infarction angina: an intravascular ultrasound radiofrequency analysis
- Right aortic arch with mirror image branching and vascular ring
- Candesartan ameliorates cardiac dysfunction observed in angiotensin-converting enzyme 2-deficient mice
- Impact of culprit plaque composition on the no-reflow phenomenon in patients with acute coronary syndrome: an intravascular ultrasound radiofrequency analysis
- Relationship between blood pressure and chronic kidney disease in the Japanese population: the lower the better even in individuals without hypertension?
- Interleukin-6-producing giant cell carcinoma of the lung with multicentric Castleman's disease-like presentation
- Relationship between coronary artery remodeling and plaque composition in culprit lesions: an intravascular ultrasound radiofrequency analysis
- Reversible left ventricular hypertrophy after tako-tsubo-like cardiomyopathy