Higashikuni Lab
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Emerging roles of the cGAS/STING pathway in cardiovascular diseases
Cardiovascular diseases (CVDs) remain the leading cause of mortality and morbidity worldwide, highlighting the need for novel …
Wataru Saitoh
,
Yasutomi Higashikuni, M.D., Ph.D., FESC
,
Oyunbileg Bavuu
,
Masataka Sata
,
Daiju Fukuda
Project
DOI
Fulminant Lupus Myocarditis as the Initial Manifestation of Systemic Lupus Erythematosus Successfully Treated with High-Dose Steroid Therapy A Case Report
Lupus myocarditis (LM) is a rare but potentially life-threatening manifestation of systemic lupus erythematosus. We report the case of …
Eri Morita
,
Kenji Harada
,
Takeshi Fujiwata
,
Masafumi Sato
,
Yusuke Suzuki
,
Shunsuke Saito
,
Yasutomi Higashikuni, M.D., Ph.D., FESC
,
Kazuomi Kario
Project
DOI
Positioning esaxerenone, a non-steroidal mineralocorticoid receptor antagonist, in the treatment of hypertension with and without hemodynamic cardiac stress
not available.
Yoshitaka Gunji
,
Yasutomi Higashikuni, M.D., Ph.D., FESC
,
Wenhao Liu, M.D.
,
Masataka Sata
Project
DOI
Sustained HIF activation in adult cardiomyocytes show transient beneficial effect in murine HFpEF model
Aims, Hypoxia-inducible factor (HIF) signalling influences cardiomyocyte differentiation, maturation, and metabolic adaptation under …
Daigo Sawaki
,
Takayuki Isagawa
,
Shigeru Sato
,
Tatsuyuki Sato
,
Hiroaki Semba
,
Hiroki Sugimoto
,
Kazutoshi Ono
,
Ariunbold Chuluun-Erdene
,
Thuc Toan Pham
,
Ryohei Tanaka
,
Toshinaru Kawakami
,
Masamichi Ito
,
Shun Minatsuki
,
Yasutomi Higashikuni, M.D., Ph.D., FESC
,
Masataka Asagiri
,
Ichiro Manabe
,
Takahide Kohro
,
Takahiro Kuchimaru
,
Yasushi Imai
,
Norihiko Takeda
Project
DOI
Compound heterozygous variants of CACNA1H change channel properties and contribute to intractable epilepsy with myoclonic-atonic seizures
The CACNA1H gene, which encodes the T-type calcium channel Cav3.2, is known to confer susceptibility to childhood absence epilepsy …
Ayumi Matsumoto
,
Go Kasuya
,
Suvd Tumurbaatar
,
Takuya Masuda
,
Kei Wakabayashi
,
Masako Kawada
,
Yasutomi Higashikuni, M.D., Ph.D., FESC
,
Kazuhiro Muramatsu
,
Koichi Nakajo
,
Hitoshi Osaka
,
Takayoshi Matsumura
Project
DOI
LPS Induces Limited Activation of Hypoxia-Inducible Factor-1a (HIF-1a) in Macrophages
Hypoxia-inducible factor-1a (HIF-1a) plays a crucial role in cellular and tissue adaptation to low oxygen conditions. Although …
Takayuki Isagawa
,
Masaki Suimye Morioka
,
Hiroaki Semba
,
Daigo Sawaki
,
Tatsuyuki Sato
,
Masaki Wake
,
Hiroki Sugimoto
,
Shigeru Sato
,
Kazutoshi Ono
,
Chuluun-Erdene Ariunbold
,
Thuc Toan Pham
,
Ryohei Tanaka
,
Toshinaru Kawakami
,
Masamichi Ito
,
Shun Minatsuki
,
Yasutomi Higashikuni, M.D., Ph.D., FESC
,
Hidemasa Bono
,
Hiroshi Harada
,
Masataka Asagiri
,
Ichiro Manabe
,
Christian Stockmann
,
Takahide Kohro
,
Takahiro Kuchimaru
,
Norihiko Takeda
Project
DOI
Mitigation of Doxorubicin Cardiotoxicity With Synergistic miRNA Combinations Identified Using Combinatorial Genetics en masse (CombiGEM)
Background, Cardiomyocyte loss occurs in acute and chronic cardiac injury, including cardiotoxicity due to chemotherapeutics like …
Yasutomi Higashikuni, M.D., Ph.D., FESC
,
Colin Platt
,
Margaret H Hastings
,
William C W Chen
,
Justin R B Guerra
,
Takeshi Tokuyama
,
Fuad Gandhi Torizal
,
Wenhao Liu, M.D.
,
Takumi Obana
,
Abraham L Bayer
,
Hannah Whipple
,
lexandra Kuznetsov
,
Ashish Yeri
,
Cole Turissini
,
Robert R Kitchen
,
Kota Shibayama
,
Takayoshi Matsumura
,
Norihiko Takeda
,
Hideki Uosaki
,
Aarti H Asnani
,
Timothy K Lu
,
Anthony Rosenzweig
Project
DOI
Chronobiological rhythms and artificial light at night in vascular physiology and pathology
not available.
Wenhao Liu, M.D.
,
Yasutomi Higashikuni, M.D., Ph.D., FESC
,
Masataka Sata
Project
DOI
Nocturnal blood pressure and left ventricular hypertrophy in patients with diabetes mellitus
not available.
Yasutomi Higashikuni, M.D., Ph.D., FESC
,
Wenhao Liu, M.D.
,
Masataka Sata
Project
DOI
Self-DNA sensing in cigarette smoke-induced vascular inflammation: the role of mitochondrial DNA release in vascular endothelial cells
not available.
Wenhao Liu, M.D.
,
Yasutomi Higashikuni, M.D., Ph.D., FESC
Project
DOI
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