Homeostatic Inflammation

Aging in Cardiovascular Medicine
Aging and cardiovascular disease will be discussed.
Jan 25, 2022 7:00 PM — 8:00 PM Tokyo, Online
Project
Pathogenic Basis of Thromboinflammation and Endothelial Injury in COVID-19: Current Findings and Therapeutic Implications
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global …
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Biodegradable Extremely-Small-Diameter Vascular Graft Made of Silk Fibroin can be Implanted in Mice
Aim, Synthetic vascular grafts are widely used in surgical revascularization, mainly for medium- to large-sized vessels. However, …
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Activation of Toll-Like Receptor 9 Impairs Blood Flow Recovery After Hind-Limb Ischemia
Background, Peripheral artery disease causes significant functional disability and results in impaired quality of life. Ischemic tissue …
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Toll-Like Receptor 9 Plays a Pivotal Role in Angiotensin II-Induced Atherosclerosis
Background Toll-like receptor ( TLR ) 9 recognizes bacterial DNA , activating innate immunity, whereas it also provokes inflammation in …
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Obesity-induced DNA released from adipocytes stimulates chronic adipose tissue inflammation and insulin resistance
Obesity stimulates chronic inflammation in adipose tissue, which is associated with insulin resistance, although the underlying …
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Pioglitazone Reduces Vascular Lipid Accumulation in Angiotensin II-Induced Hypertensive Rat
Aim, In an insulin-resistant state, excess lipids may accumulate in various non-adipose tissues, leading to histological and functional …
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Endothelial PGC-1α mediates vascular dysfunction in diabetes
Endothelial dysfunction is a central hallmark of diabetes. The transcriptional coactivator PGC-1α is a powerful regulator of …
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HMGB1 plays a critical role in vascular inflammation and lesion formation via toll-like receptor 9
Objective, Endogenous ligands such as high-mobility group box 1 (HMGB1) and nucleic acids are released by dying cells and bind to …
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Toll-like receptor-2 mediates adaptive cardiac hypertrophy in response to pressure overload through interleukin-1β upregulation via nuclear factor κB activation
Background, Inflammation is induced in the heart during the development of cardiac hypertrophy. The initiating mechanisms and the role …
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