Higashikuni Lab
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Automatic
Homeostatic Inflammation
The ATP-binding cassette transporter ABCG2 protects against pressure overload-induced cardiac hypertrophy and heart failure by promoting angiogenesis and antioxidant response
Objective, ATP-binding cassette transporter subfamily G member 2 (ABCG2), expressed in microvascular endothelial cells in the heart, …
Yasutomi Higashikuni, M.D., Ph.D., FESC
,
Julie Sainz
,
Kazuto Nakamura
,
Minoru Takaoka
,
Soichiro Enomoto
,
Hiroshi Iwata
,
Kimie Tanaka
,
Makoto Sahara
,
Yasunobu Hirata
,
Ryozo Nagai
,
Masataka Sata
Project
DOI
Aliskiren in combination with valsartan exerts synergistic protective effects against ventricular remodeling after myocardial infarction in mice
The efficacy of aliskiren, a direct renin inhibitor, in ventricular remodeling after myocardial infarction (MI) compared with …
Yasutomi Higashikuni, M.D., Ph.D., FESC
,
Minoru Takaoka
,
Hiroshi Iwata
,
Kimie Tanaka
,
Yasunobu Hirata
,
Ryozo Nagai
,
Masataka Sata
Project
DOI
The ATP-binding cassette transporter BCRP1/ABCG2 plays a pivotal role in cardiac repair after myocardial infarction via modulation of microvascular endothelial cell survival and function
Objective, To clarify the impact of breast cancer resistance protein 1 (BCRP1)/ATP-binding cassette transporter subfamily G member 2 …
Yasutomi Higashikuni, M.D., Ph.D., FESC
,
Julie Sainz
,
Kazuto Nakamura
,
Minoru Takaoka
,
Soichiro Enomoto
,
Hiroshi Iwata
,
Makoto Sahara
,
Kimie Tanaka
,
Nobutaka Koibuchi
,
Sumito Ito
,
Hiroyuki Kusuhara
,
Yuichi Sugiyama
,
Yasunobu Hirata
,
Ryozo Nagai
,
Masataka Sata
Project
DOI
Serum osteoprotegerin levels and long-term prognosis in subjects with stable coronary artery disease
Background, Osteoprotegerin (OPG) is a secretory glycoprotein which belongs to the tumor necrosis factor receptor family. OPG …
S. Jono
,
S. Otsuki
,
Yasutomi Higashikuni, M.D., Ph.D., FESC
,
A. Shioi
,
K. Mori
,
K. Hara
,
H. Hashimoto
,
Y. Ikari
Project
DOI
Difference of culprit plaque composition between patients with and without pre-infarction angina: an intravascular ultrasound radiofrequency analysis
Aims, This study was performed to assess the differences in culprit plaque composition between patients with and without pre-infarction …
Yasutomi Higashikuni, M.D., Ph.D., FESC
,
Kengo Tanabe
,
Shuzou Tanimoto
,
Jiro Aoki
,
Hirosada Yamamoto
,
Gaku Nakazawa
,
Ruri Chihara
,
Yoshinobu Onuma
,
Shuji Otsuki
,
Atsuhiko Yagishita
,
Sen Yachi
,
Hiroyoshi Nakajima
,
Kazuhiro Hara
DOI
Candesartan ameliorates cardiac dysfunction observed in angiotensin-converting enzyme 2-deficient mice
The renin-angiotensin (Ang) system plays a critical role in the regulation of blood pressure, body fluid, electrolyte homeostasis, and …
Kazuto Nakamura
,
Nobutaka Koibuchi
,
Hiroaki Nishimatsu
,
Yasutomi Higashikuni, M.D., Ph.D., FESC
,
Yasunobu Hirata
,
Kiyotaka Kugiyama
,
Ryozo Nagai
,
Masataka Sata
Project
DOI
Impact of culprit plaque composition on the no-reflow phenomenon in patients with acute coronary syndrome: an intravascular ultrasound radiofrequency analysis
Background, The difference in the culprit plaque composition of acute coronary syndrome (ACS) patients with and without the no-reflow …
Yasutomi Higashikuni, M.D., Ph.D., FESC
,
Kengo Tanabe
,
Shuzou Tanimoto
,
Jiro Aoki
,
Hirosada Yamamoto
,
Gaku Nakazawa
,
Ruri Chihara
,
Yoshinobu Onuma
,
Shuji Ohtsuki
,
Atsuhiko Yagishita
,
Sen Yachi
,
Hiroyoshi Nakajima
,
Kazuhiro Hara
Project
DOI
Interleukin-6-producing giant cell carcinoma of the lung with multicentric Castleman's disease-like presentation
We encountered a 59-year-old man with advanced lung cancer with multiple swollen lymph nodes. At autopsy the lung cancer was revealed …
Yasutomi Higashikuni, M.D., Ph.D., FESC
,
Masaya Mori
,
Hiroyoshi Kino
Project
DOI
Relationship between coronary artery remodeling and plaque composition in culprit lesions: an intravascular ultrasound radiofrequency analysis
Background, The relationship between coronary artery remodeling and culprit plaque composition in vivo has not been fully evaluated by …
Yasutomi Higashikuni, M.D., Ph.D., FESC
,
Kengo Tanabe
,
Hirosada Yamamoto
,
Jiro Aoki
,
Gaku Nakazawa
,
Yoshinobu Onuma
,
Shuji Otsuki
,
Atsuhiko Yagishita
,
Sen Yachi
,
Hiroyoshi Nakajima
,
Kazuhiro Hara
Project
DOI
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